Nattokinase: A Natural Heart Health Supplement

In the era of natural health supplements, Nattokinase, derived from the traditional Japanese food Natto, has been gaining attention for its remarkable properties. Let's dive into what makes Nattokinase a promising addition to your wellness routine and explore its potential benefits.

What is Nattokinase?

Natto is a traditional Japanese food crafted by fermenting boiled soybeans with Bacillus subtilis bacteria. Nattokinase is an enzyme extracted from Natto, a fermented soybean dish. Initially thought to be a kinase, Nattokinase's key attribute lies in its ability to enzymatically degrade fibrin, a protein involved in blood clot formation.

Why do we need nattokinase?

Nattokinase is believed to support heart health by enhancing the activities of natural proteins in your body, like tissue plasminogen activator (tPA) and urokinase, which help break down blood clots. When nattokinase breaks down, it creates bioactive peptides that could lower blood pressure by reducing renin activity and angiotensin II (Angiotensin II narrows your blood vessels and limits the blood flow). Also, it can directly break down fibrin, a key part of blood clots.

Benefits of Nattokinase:

    • Cardiovascular Health:

Nattokinase is touted as a safe and effective supplement for maintaining heart health. By thinning the blood and dissolving blood clots, it supports optimal circulation and reduces the risk of cardiovascular issues.

    • Anti-Alzheimer's Effect:

Nattokinase shows promise in combating Alzheimer's disease by targeting abnormal proteins such as β-amyloid (Aβ) and Tau proteins. These proteins tend to aggregate, forming plaques and neurofibrillary tangles that disrupt brain function. Besides its ability to dissolve blood clots, Nattokinase also demonstrates effectiveness in breaking down Aβ, hinting at its potential therapeutic role in preventing Alzheimer's disease.

    • Antitumor Properties:

Nattokinase has the potential to prevent breast cancer and inhibit the activity of FOXM1 and MMP2, which are transcription factors promoting the growth of cancer stem cells in tumour tissue. This offers new perspectives for future breast cancer treatment approaches.

    • Lipid-Lowering and Anti-Atherosclerotic Effects:

Hyperlipidemia is a condition marked by abnormal lipid metabolism, often resulting in high levels of total cholesterol (TC) and triglycerides (TG), or low levels of high-density lipoprotein cholesterol (HDL-C) in the bloodstream. Numerous studies have shown that the intake of nattokinase or its derivatives can notably decrease TC and TG levels while boosting HDL-C levels. This highlights its significant hypolipidemic properties. Furthermore, nattokinase not only aids in lowering lipid levels but also shows promise in combating atherosclerosis.

Who Can Benefit from Nattokinase?

For individuals with hypertension:

The renin-angiotensin system (hormonal system that helps regulate blood pressure), plays a crucial role in regulating blood pressure. Angiotensin II, a key player in this system, increases blood pressure by affecting blood vessels, sympathetic nerves, and adrenal glands. Research suggests that natto, a traditional Japanese food, contains antihypertensive substances that inhibit ACE (angiotensin-converting enzyme). Studies have shown that supplementation with nattokinase, can lead to reductions in both systolic blood pressure (SBP) and diastolic blood pressure (DBP).


Regular supplementation with nattokinase has been found to be effective in slowing down the progression of atherosclerosis, a condition marked by the narrowing and hardening of arteries due to plaque accumulation. By preventing the formation of blood clots, nattokinase can reduce the size of arterial plaques, thereby lowering the risk of cardiovascular events like heart attacks and strokes. Studies have demonstrated a notable reduction in arterial wall thickness with consistent nattokinase intake, highlighting its potential to improve cardiovascular health.

For Stroke patients:

It's commonly understood that what benefits the heart can also benefit the brain. Healthy circulation and enhanced blood flow are crucial for safeguarding the brain from oxygen deprivation during the formation of harmful blood clots. Research on stroke patients has shown that nattokinase can notably decrease the rise in fibrinogen levels following a stroke and decrease the severity of the stroke itself. Nattokinase is believed to offer neuroprotective effects by preventing the aggregation of platelets, which aid in clot formation, and by preserving injured cells from premature death.

Cancer patients:

Nattokinase can help dissolve the fibrin coating around a tumour and has the potential to prevent breast cancer and inhibit the activity of FOXM1 and MMP2, which are transcription factors promoting the growth of cancer stem cells in tumour tissue. Please consult with your healthcare practitioner before consuming.

Consumption and Dosage:

In comparison to traditional thrombolytic drugs such as urokinase and streptokinase, nattokinase presents several advantages including enhanced safety, suitability for long-term use, and ease of oral administration. Available in tablet and capsule forms, nattokinase supplements offer convenience and accessibility.

Numerous studies have indicated that nattokinase may serve as a preferable alternative to statins, commonly prescribed for reducing atherosclerosis. 

Nattokinase supplements are widely accessible and typically recommended at dosages ranging from 100 to 200 mg per day. Nonetheless, consulting with a healthcare professional prior to initiating any new supplement routine is essential.

NATTIASE® -the power of nattokinase

Natto has been a part of Japanese culture for centuries, cherished in family kitchens and traditions. Inside natto hides Nattokinase, a valuable asset of Nattiase®, representing the essence of Japanese longevity. 

Nattiase is a brand or product name associated with a fermented soybean extract that is rich in nattokinase. Nattiase is dedicated to providing high-quality nattokinase products with competitive advantages and top-notch quality, ensuring its accessibility to consumers while prioritising food safety.

Origins Nutra Nattokinase:

The Nattiase® Nattokinase supplement by Origin's Nutra is meticulously crafted to promote heart health. Derived from fermented soybean extract, this premium supplement undergoes rigorous quality checks to meet safety standards. With certifications such as HALAL and KOSHER, and adherence to the FSSC 22000 food safety management framework, Origins Nutra ensures the efficacy and reliability of their Nattokinase product.

In conclusion, Nattokinase emerges as a natural powerhouse for heart health and overall well-being, offering a multitude of benefits backed by scientific research. Incorporating Nattokinase into your daily regimen could be a proactive step towards nurturing your cardiovascular health and promoting vitality.

Reference Links:


Leave a comment

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.