The science behind nattokinase
What if the key to a stronger heart and a longer life had been quietly sitting on Japanese dinner tables for centuries? A humble dish called natto ( fermented soybean) has been a staple in Japan for generations, but its true power goes far beyond tradition.

Scientists have long been intrigued by Japan’s exceptional heart health and longevity, and their research led them to a remarkable discovery: Nattokinase—a potent enzyme hidden within natto that supports circulation and cardiovascular function.
Now, this ancient secret is available to the world in supplement form, delivering its heart-protective benefits in a precise, standardized dose. Could this be the missing piece in your heart health journey? Let’s explore.
What is nattokinase?
Nattokinase is a powerful enzyme found in natto that helps keep your blood flowing smoothly. As a natural fibrinolytic enzyme, it works by breaking down excess fibrin (a protein involved in blood clot formation).
Unlike pharmaceutical blood thinners, nattokinase works naturally with your body, making it a gentler option for supporting circulation and overall heart health.
How does nattokinase work?
Your body has a built-in system to break down blood clots when they’re no longer needed. The key player in this process is plasmin, an enzyme that dissolves fibrin—the sticky protein that holds clots together. But plasmin doesn’t just work on its own; it needs to be activated from plasminogen by enzymes like tPA (tissue plasminogen activator) and urokinase.

However, as we age or face lifestyle-related challenges, this natural process can slow down, leading to poor circulation and increased clot formation. This is where nattokinase steps in to enhance and support your body’s fibrinolytic (clot-dissolving) activity.
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Boosts Clot-Breaking Enzymes – Nattokinase activates tPA and urokinase, helping convert plasminogen into plasmin—the enzyme that dissolves fibrin clots.
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Promotes Smoother Blood Flow – By breaking down excess fibrin, nattokinase supports healthy circulation, reducing the risk of unwanted clot buildup.
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Balances the System – Nattokinase lowers PAI-1, a protein that can slow down clot breakdown. This helps maintain the right balance between clot formation and clearance.
Key health benefits of nattokinase
1. Supports Healthy Blood Pressure
Research suggests that nattokinase can help regulate blood pressure by reducing fibrin buildup and improving blood vessel flexibility. It may also help regulate angiotensin-converting enzyme (ACE), which affects how blood vessels contract and relax.
2. Promotes Circulatory Health
Poor circulation can cause fatigue, swelling, and cold hands and feet. Nattokinase keeps blood flowing smoothly, reducing the risk of clot formation while ensuring your body gets the oxygen and nutrients it needs.
3. Supports Brain Function & Cognitive Health
Healthy circulation is crucial for brain function and memory. Nattokinase enhances oxygen-rich blood flow to the brain, which may support cognitive function and reduce the risk of age-related cognitive decline.
4. Aids in Healthy Cholesterol & Lipid Metabolism
Balanced cholesterol levels contribute to overall heart health. Nattokinase may help maintain healthy cholesterol levels by promoting circulation and assisting in the breakdown of excess fibrin deposits that affect vascular health.
How does nattokinase compare to conventional blood thinners?
Unlike traditional blood thinners such as aspirin or warfarin, nattokinase works naturally without directly affecting platelet aggregation. This means it supports healthy circulation without excessively thinning the blood or interfering with normal clotting mechanisms.
However, individuals on blood-thinning medications should consult a healthcare provider before taking nattokinase.
Who can benefit from nattokinase?
Nattokinase may be beneficial for:
- For those looking to maintain healthy blood pressure
- For ones aiming to manage cholesterol levels effectively
- For those seeking to promote healthy blood circulation
- For those working to naturally balance inflammation
- For ones striving to improve overall heart health
How to take nattokinase
For best results, nattokinase is typically taken in common dosage ranges from 100-200 mg daily, but it's always best to follow product recommendations or consult a healthcare provider.
Choosing a high-quality nattokinase supplement
When selecting a nattokinase supplement, look for:
- Standardized potency (measured in fibrinolytic activity units),
- Non-GMO,
- FDA approved.
Final thoughts:
Nattokinase offers a natural, science-backed way to support cardiovascular health and circulation. With its fibrinolytic properties and ability to promote healthy blood flow, it can be an excellent addition to a heart-healthy lifestyle. As with any supplement, consult a healthcare provider to ensure it aligns with your health needs.
Unlock the power of nattokinase and take a step toward better heart health—naturally!
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